The Red Devils have returned to form recently and returned from the international break with a 2-1 win over Brighton.
United followed that win with a 2-0 victory in Spain against Granada in the Europa League.
Meanwhile, Spurs were frustrated in their last outing as a late Joe Willock equaliser earned Newcastle a 2-2 draw.
In one of the key battles in this game, England teammates Harry Maguire and Kane will be up against each other, with the United defender eager to build on momentum from the Brighton win: “It’s a great game to be involved in. Really pleased that we’re going into it on the back of three points against Brighton (last weekend). Take that little bit of momentum into the game.
“It’s always a tough game after the international break and I always feel like the points are the big thing - you don’t really look at the performance. Spurs is going to be a big one. It’s one that we’re looking forward to. We had a bad result against them at Old Trafford this season, so we’ll be looking to get one back.”
Here’s everything you need to know about the match:
When is it?
The fixture will kick-off at 4:30pm GMT at the Tottenham Hotspur Stadium.
How can I watch it?
The match is live on Sky Sports Premier League and Main Event with coverage starting from 4pm GMT.
If you’re not a Sky customer you can grab a NOWTV Day Pass here to watch without a subscription. We may earn commission from some of the links in this article, but we never allow this to influence our content.
Tottenham XI: Lloris, Aurier, Rodon, Dier, Reguilon, Højbjerg, Ndombele, Lo Celso, Lucas, Son, Kane.
Man United XI: Henderson, Wan-Bissaka, Lindelof, Maguire, Shaw, McTominay, Pogba, Fred, Fernandes, Rashford, Cavani
Manchester United: 7/5
This is a tight one to call. United are in the ascendency, but both sides have the potential to rip the other apart. 2-2.