The odds are firmly stacked against the League Two side, who have never beaten Premier League opposition in the domestic cups.
City are on a nine-match winning streak across all competitions, though while Cheltenham are unbeaten in five in the league they will be looking at their own promotion hopes more than a cup run.
The winners will face either Swansea City or Nottingham Forest in early February for a place in the quarter-finals.
Date, time and venue
Cheltenham vs Manchester City is scheduled for an 5.30pm GMT kick-off on Saturday, January 23, 2021.
The match will be held behind closed doors at the Jonny Rocks Stadium.
How to watch
TV channel: The match will be televised on BBC One.
Live stream: UK viewers will be able to watch the match online via the BBC Sport website or BBC iPlayer.
Manchester City will once again be without Sergio Aguero, this time due to a positive coronavirus test. Gabriel Jesus should start after coming off the bench in the win over Aston Villa.
Younger players, like Zack Steffen in goal, should get another chance to impress. Tommy Doyle, Taylor Harwood-Bellis and Cole Palmer are all in Pep Guardiola's thinking.
Cheltenham are expected to be without Elliot Bonds and Chris Hussey, though Sean Long could feature from the bench.
Prediction: Cheltenham 0-3 Man City
Cheltenham are enjoying a fine run of late, unbeaten in five games, but this Pep Guardiola’s Manchester City. Should be a cakewalk for the Premier League side inside 90 minutes.
Head to head (h2h) history and results
This is the first meeting between the two sides.
Bettings odds and tips (subject to change)
Cheltenham win: 14/1
Man City win: 1/80
Man City to win 3-0: 5/1
Odds via Betfair Exchange. Click here to find out more.
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