While this is most often associated with biotech companies that could be a hit or fade away based on a regulatory decision, it's also been the reality for Upstart (NASDAQ: UPST). Upstart offers an alternative way to assess creditworthiness rather than a traditional FICO score and uses artificial intelligence (AI) to assess a loan applicant. The stock has plummeted more than 90% from its highs, although Upstart has rebounded in the past few months.