Alcoa and MannKind are big market movers

NEW YORK (AP) -- Stocks that moved substantially or traded heavily Wednesday on the New York Stock Exchange and the Nasdaq Stock Market:

NYSE

Alcoa Inc., down 19 cents to $12.85

Falling prices and not much leverage to seek higher premiums could weigh on the aluminum maker, according to analysts with Nomura.

Tyson Foods Inc., down $2.01 to $41.44

Shares of the food producer are at all-time highs but corn crops are shrinking, according to the USDA, which could drive up costs.

DSW Inc., up 56 cents to $37.37

A sharp decline in the retailer's share price brings an upgrade from Brean Capital, which no longer rates the company as a 'sell.'

Nasdaq

MannKind Corp., up $2.97 to $6.99

FDA advisers voted to recommend approval of the drug Afrezza, the pharmaceutical's fast-acting insulin, for patients with diabetes.

Apollo Education Group Inc., down $3.10 to $32.06

A full-year outlook for sales disappointed investors and overshadowed the for-profit educator's strong second-quarter profit.

Myriad Genetics Inc., up $4.03 to $39.18

The molecular diagnostic company says reimbursement cuts from Medicare for genetic tests will be less than had been feared.

GT Advanced Technologies Inc., up $1.29 to $18.67

Goldman Sachs upped its price target on the consumer electronics supplier, saying the next iPhone could provide a stock jolt.

Urban Outfitters Inc., up $1.46 to $38.11

Comparable-store sales growth will fall to the low, single-digits at the retailer, but that was better than many had expected.