0.01%	% of shares held by all insiders
1.86%	% of shares held by institutions
1.86%	% of float held by institutions
326	Number of institutions holding shares

Holder	Shares	Date reported	% out	Value
Mondrian Investment Partners Ltd	4,319,715	30 Mar 2022	0.14%	61,858,318
Goldman Sachs Group Inc	4,242,689	30 Mar 2022	0.13%	60,755,306
Macquarie Group Limited	4,221,381	30 Mar 2022	0.13%	60,450,175
Parametric Portfolio Associates LLC	4,256,356	30 Mar 2022	0.13%	60,951,017
Bank of America Corporation	3,387,908	30 Mar 2022	0.11%	48,514,842
Blackrock Inc.	3,021,274	30 Mar 2022	0.10%	43,264,643
FMR, LLC	2,448,204	30 Mar 2022	0.08%	35,058,281
Brandes Investment Partners L.P.	2,109,846	30 Mar 2022	0.07%	30,212,994
Northern Trust Corporation	2,219,358	30 Mar 2022	0.07%	31,781,206
Renaissance Technologies, LLC	1,993,200	30 Mar 2022	0.06%	28,542,624

Holder	Shares	Date reported	% out	Value
VanEck ETF Trust-VanEck Pharmaceutical ETF	1,433,700	30 May 2022	0.05%	20,659,617
Vanguard Tax Managed Fund-Vanguard Developed Markets Index Fund	1,102,384	30 Mar 2022	0.03%	15,786,138
First Trust International Equity Opportunities ETF	669,944	30 May 2022	0.02%	9,653,893
Pacer Global Cash Cows Dividend ETF	188,686	30 Jan 2022	0.01%	2,728,399
Vanguard Intl Equity Index Fds-FTSE All World ex U.S. Index Fund	241,817	30 Jan 2022	0.01%	3,496,673
Tekla World Healthcare Fund	210,146	30 Mar 2022	0.01%	3,009,290

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Takeda Pharmaceutical Company Limited (TAK)