13.54%	% of shares held by all insiders
54.99%	% of shares held by institutions
63.60%	% of float held by institutions
61	Number of institutions holding shares

Holder	Shares	Date reported	% out	Value
Slate Path Capital, LP	7,157,601	30 Mar 2022	16.47%	7,014,449
MFN Partners Management, LP	3,389,215	30 Mar 2022	7.80%	3,321,430
Artal Group S.A.	2,779,122	30 Mar 2022	6.40%	2,723,539
FMR, LLC	2,615,010	30 Mar 2022	6.02%	2,562,709
Vanguard Group, Inc. (The)	1,754,153	30 Mar 2022	4.04%	1,719,069
Pura Vida Investments, LLC	776,497	30 Mar 2022	1.79%	760,967
Geode Capital Management, LLC	583,383	30 Mar 2022	1.34%	571,715
Ikarian Capital, LLC	527,462	30 Mar 2022	1.21%	516,912
Blackrock Inc.	441,380	30 Mar 2022	1.02%	432,552
Eversept Partners, LP	371,955	30 Mar 2022	0.86%	364,515

Holder	Shares	Date reported	% out	Value
Vanguard Total Stock Market Index Fund	1,241,708	30 Mar 2022	2.86%	1,216,873
Fidelity Select Portfolios - Biotechnology	837,285	30 May 2022	1.93%	820,539
Vanguard Extended Market Index Fund	468,984	30 Mar 2022	1.08%	459,604
Fidelity Growth Company Fund	229,594	30 May 2022	0.53%	225,002
Fidelity NASDAQ Composite Index ETF	207,500	30 May 2022	0.48%	203,350
Fidelity Extended Market Index Fund	203,578	30 May 2022	0.47%	199,506
Legg Mason Global Asset Mgt Tr-Franklin U.S. Small Cap Equity Fd	113,435	30 Mar 2022	0.26%	111,166
Bridgeway Funds Inc-Ultra Small Company Market Fund	107,000	30 Mar 2022	0.25%	104,860
iShares Micro Cap ETF	74,979	30 May 2022	0.17%	73,479
Fidelity NASDAQ Composite Index Fund	50,166	30 May 2022	0.12%	49,162
Fidelity Growth Company K6 Fund	49,491	30 May 2022	0.11%	48,501
Fidelity Series Total Market Index Fund	46,517	30 May 2022	0.11%	45,586
Fidelity Total Market Index Fund	45,211	30 May 2022	0.10%	44,306
Vanguard Balanced Index Fund	23,450	30 Mar 2022	0.05%	22,981

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