Tokyo stocks opened 0.24 percent lower on Friday after Japan and the United States failed to strike a deal over a Pacific-wide trade pact during President Barack Obama's visit.
The Nikkei 225 index fell 35.27 points to 14,369.72 at the start.
Japan's economy minister Akira Amari said early Friday that Tokyo had not reached a broad agreement with Washington over a Pacific-wide trade deal despite intense talks after a bilateral summit.
It dashed hopes that Tokyo and Washington might break an impasse in the stalled talks before US President Barack Obama's visit to Tokyo. He is to leave Tokyo soon.
US stocks Thursday finished mostly higher although concerns about rising tensions in Ukraine cast a shadow over largely positive earnings results from Apple and other large companies.
The tech-rich Nasdaq Composite Index jumped 0.52 percent to 4,148.34, while the Dow Jones Industrial Average was unchanged at 16,501.65.
Currency rates were largely unmoved after official data showed Japan's consumer inflation rose for a 10th straight month in March.
Stripping out volatile fresh food prices, prices rose 1.3 percent year-on-year in March, the same rate since December, data from the internal affairs ministry showed.
The dollar was little changed at 102.31 yen early Friday from 102.32 yen in New York Thursday afternoon.
The euro bought $1.3828 and 141.50 yen compared with $1.3830 and 141.53 yen in US trade.