Under Ole Gunnar Solskjaer, United have laboured at times in the early stages of the season but they sit level at the top of the table with Chelsea and Liverpool on 13 points.
Cristiano Ronaldo will be out to continue his good goalscoring form after four goals in his first three games back at Old Trafford.
It is unlikely to be easy for United against a Villa side who look to be getting into their stride after an impressive 3-0 win over Everton last weekend.
Date, kick-off time and venue
Manchester United vs Aston Villa is scheduled for an 12:30pm BST kick-off at Old Trafford on Saturday.
Where to watch Man United vs Aston Villa
Today’s match will not be broadcast live on TV in the UK.
Man United vs Aston Villa team news
Solskjaer makes 11 changes to the Manchester United side that was beaten by West Ham in the Carabao Cup in midweek and reverts back to the team that beat the Hammers 2-1 last Sunday.
That means Ronaldo is back to lead the United attack, with the returning Edinson Cavani on the bench.
For Villa, Dean Smith makes one change to the team that beat Everton 3-0 last weekend.
Axel Tuanzebe is unable to feature against his parent club so Kortney Hause comes in at Old Trafford for his first Premier League start of the season.
Man United vs Aston Villa prediction
United have flattered the deceive at times this season but they should have too much for a Villa side still finding its feet without Jack Grealish.
Man United 3-0 Aston Villa.
Head to head (h2h) history and results
(Premier League fixtures only)
Man United wins: 37
Villa wins: 3
Betting odds and tips
Man United to win: 2/5
Aston Villa to win: 7/1
Odds via Betfair (subject to change). Click here to find out more.