| INSIDER & RULE 144 TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Transaction | Value* | | 7-Jan-10 | NOVO NORDISK A S Beneficial Owner (10% or more) | 1,250,000 | Purchase at $6 per share. | $7,500,000 | | 7-Dec-09 | JOHNSON JAMES A Officer | 10,000 | Option Exercise at $2.78 per share. | $27,800 | | 7-Dec-09 | JOHNSON JAMES A Officer | 10,000 | Sale at $7 per share. | $70,000 | | 16-Sep-09 | MILLER DENNIS M. Officer | 6,761 | Statement of Ownership | N/A | | 31-Aug-09 | JOHNSON JAMES A Officer | 10,000 | Option Exercise at $2.78 per share. | $27,800 | | 31-Aug-09 | JOHNSON JAMES A Officer | 10,000 | Sale at $6 per share. | $60,000 | | 10-Jun-09 | RAMOS ELEANOR Officer | 6,761 | Statement of Ownership | N/A | | 30-May-08 | FRANKLIN HEATHER L Officer | 7,600 | Statement of Ownership | N/A | | 7-Mar-08 | LEFF JONATHAN S Director | 56,722 | Purchase at $8.51 - $8.8 per share. | $491,0002 | | 7-Mar-08 | WARBURG PINCUS EQUITY PARTNERS LP Beneficial Owner (10% or more) | 56,722 | Purchase at $8.51 - $8.8 per share. | $491,0002 | | 5-Mar-08 | LEFF JONATHAN S Director | 98,254 | Purchase at $9.17 - $9.48 per share. | $916,0002 | | 5-Mar-08 | WARBURG PINCUS EQUITY PARTNERS LP Beneficial Owner (10% or more) | 98,254 | Purchase at $9.17 - $9.48 per share. | $916,0002 | | 3-Mar-08 | LEFF JONATHAN S Director | 139,536 | Purchase at $9.49 - $9.8 per share. | $1,346,0002 | | 3-Mar-08 | WARBURG PINCUS EQUITY PARTNERS LP Beneficial Owner (10% or more) | 139,536 | Purchase at $9.49 - $9.8 per share. | $1,346,0002 | | 29-Feb-08 | LEFF JONATHAN S Director | 93,009 | Purchase at $9.96 - $10.1 per share. | $933,0002 | | 29-Feb-08 | WARBURG PINCUS EQUITY PARTNERS LP Beneficial Owner (10% or more) | 93,009 | Purchase at $9.96 - $10.1 per share. | $933,0002 | | 28-Feb-08 | LEFF JONATHAN S Director | 10,142 | Purchase at $9.85 - $10 per share. | $101,0002 | | 28-Feb-08 | WARBURG PINCUS EQUITY PARTNERS LP Beneficial Owner (10% or more) | 10,142 | Purchase at $9.85 - $10 per share. | $101,0002 | | 26-Feb-08 | LEFF JONATHAN S Director | 1,900 | Purchase at $9.45 - $9.5 per share. | $18,0002 | | 26-Feb-08 | WARBURG PINCUS EQUITY PARTNERS LP Beneficial Owner (10% or more) | 1,900 | Purchase at $9.45 - $9.5 per share. | $18,0002 | | 25-Feb-08 | LEFF JONATHAN S Director | 145,000 | Purchase at $9.40 - $9.73 per share. | $1,387,0002 | | 25-Feb-08 | WARBURG PINCUS EQUITY PARTNERS LP Beneficial Owner (10% or more) | 145,000 | Purchase at $9.40 - $9.73 per share. | $1,387,0002 | | 21-Feb-08 | LEFF JONATHAN S Director | 96,570 | Purchase at $9.02 - $9.32 per share. | $886,0002 | | 21-Feb-08 | WARBURG PINCUS EQUITY PARTNERS LP Beneficial Owner (10% or more) | 96,570 | Purchase at $9.02 - $9.32 per share. | $886,0002 | | 20-Feb-08 | WILLIAMS DOUGLAS E Officer | 2,500 | Purchase at $8.99 per share. | $22,475 | | 19-Feb-08 | CARTER BRUCE L A Officer | 11,000 | Purchase at $9.13 per share. | $100,430 |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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