| INSIDER & RULE 144 TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Transaction | Value* | | 15-Aug-08 | SCHUYLER ANDREW P Officer | 150,000 | Disposition (Non Open Market) at $7 per share. | $1,050,000 | | 15-Aug-08 | SMITH CARL E Officer | 45,382 | Disposition (Non Open Market) at $7 per share. | $317,674 | | 15-Aug-08 | ST CLAIR DAVID Officer | 1,890,731 | Disposition (Non Open Market) at $7 per share. | $13,235,117 | | 15-Aug-08 | MORSE THOMAS R Director | 1,447,418 | Disposition (Non Open Market) at $7 per share. | $10,131,926 | | 15-Aug-08 | MORSE THOMAS R Director | 23,581 | Disposition (Non Open Market) at $7 per share. | $165,067 | | 8-Jul-08 | GREAT POINT PARTNERS LLC Beneficial Owner (10% or more) | 190,240 | Sale at $6.57 - $6.58 per share. | $1,251,0002 | | 7-Jul-08 | GREAT POINT PARTNERS LLC Beneficial Owner (10% or more) | 25,192 | Sale at $6.61 per share. | $166,519 | | 1-Jul-08 | GREAT POINT PARTNERS LLC Beneficial Owner (10% or more) | 161,755 | Sale at $6.65 per share. | $1,075,670 | | 1-Jul-08 | GREAT POINT PARTNERS LLC Beneficial Owner (10% or more) | 161,755 | Purchase at $6.65 per share. | $1,075,670 | | 2-May-08 | SMITH CARL E Officer | 4,500 | Acquisition (Non Open Market) at $2.26 per share. | $10,169 | | 21-Apr-08 | SCHUYLER ANDREW P Officer | 150,000 | Statement of Ownership | N/A | | 26-Mar-08 | GREAT POINT PARTNERS LLC Beneficial Owner (10% or more) | 970,542 | Statement of Ownership | N/A | | 17-Mar-08 | MARXE AUSTIN W & GREENHOUSE DAVID M Beneficial Owner (10% or more) | 200 | Purchase at $1.10 per share. | $220 | | 28-Feb-08 | MARXE AUSTIN W & GREENHOUSE DAVID M Beneficial Owner (10% or more) | 100 | Purchase at $1.99 per share. | $199 | | 29-Jan-08 | MARXE AUSTIN W & GREENHOUSE DAVID M Beneficial Owner (10% or more) | 1,700 | Purchase at $2.10 per share. | $3,570 | | 24-Jan-08 | MARXE AUSTIN W & GREENHOUSE DAVID M Beneficial Owner (10% or more) | 56,100 | Purchase at $2.15 per share. | $120,615 |
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* = Where indicated, some values are estimates. 1 = Potential proceeds estimated by the filer. 2 = Estimated based on the average of multiple prices reported. 3 = Multiple dates reported. Most recent date shown. |
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